Wake Forest (2-1) at No. 16 Louisville (2-1), Sept. 26 at 12 p.m. EDT.

Opening Line: Louisville by 13.5. Against the spread: Louisville 3-0, Wake Forest 1-2.

How to watch: ESPN

Key stats

Louisville Offense

Overall: 515.3 yards per game (12th in FBS)

Passing: 286.3 yards per game (29th)

Rushing: 229.0 yards per game (26th)

Scoring: 46.0 points per game (12th)

Louisville Defense

Overall: 406.7 yards per game (110th in FBS)

Passing: 245.3 yards per game (113th)

Rushing: 161.3 yards per game (104th)

Scoring: 28.3 points per game (108th)

Wake Forest Offense

Overall: 434.7 yards per game (50th in FBS)

Passing: 297.7 yards per game (25th)

Rushing: 137.0 yards per game (102nd)

Scoring: 32.0 points per game (66th)

Wake Forest Defense

Overall: 379.3 yards per game (99th in FBS)

Passing: 235.0 yards per game (103rd)

Rushing: 144.3 yards per game (86th)

Scoring: 28.3 points per game (108th)

Wake Forest ranks 66th in the FBS with an even turnover margin, compared to Louisville's 6th-ranked +6 margin.

Both teams are heavily penalized. Louisville ranks 134th in the FBS averaging 94.0 penalty yards per game, and Wake Forest ranks 136th with a 95.7-yard average.

Wake Forest is 109th in FBS in red zone defense, allowing opponents to score on 100.0% of trips. Louisville's red zone offense ranks 1st, scoring on 100.0% of red zone opportunities.

Wake Forest is 113th in the FBS with an average time of possession of 27:56.

Team leaders

Louisville

Passing: Lincoln Kienholz, 816 yards, 6 TDs, 0 INTs, 65.8 completion percentage

Rushing: Keyjuan Brown, 231 yards on 18 carries, 2 TDs

Receiving: Tre Richardson, 243 yards on 15 catches, 1 TD

Wake Forest

Passing: Gio Lopez, 887 yards, 7 TDs, 1 INT, 62.9 completion percentage

Rushing: Ty Clark, 144 yards on 22 carries, 1 TD

Receiving: Carlos Hernandez, 322 yards on 21 catches, 2 TDs

Last game

Louisville won 41-31 over SMU on Sept. 19. Kienholz passed for 177 yards on 14-of-23 attempts (60.9%) with two touchdowns and no interceptions. He also carried the ball 12 times for 42 yards and one rushing touchdown. Brown carried the ball 10 times for 163 yards and scored two touchdowns. Richardson had four receptions for 62 yards.

Wake Forest fell 33-20 to Miami (FL) on Sept. 18. Lopez threw for 312 yards on 29-of-46 attempts (63.0%) with three touchdowns and one interception. Deuce Lawrence had 27 rushing yards on six carries, adding one reception for 14 yards. Jack Foley put up 118 yards on six catches with one touchdown.

Next game

Louisville plays at NC State on Oct. 3. Wake Forest hosts Stanford on Oct. 3.