ST. PETERSBURG, Fla. (AP) — For six innings, the Tampa Bay Rays were in complete control again.

Then they unraveled in a hurry.

Drew Rasmussen squandered a two-run lead on the mound, Tampa Bay's bullpen let the game get away and the Rays stumbled to a 7-3 loss against the Cleveland Guardians in their American League Championship Series opener Monday night.

Staked to a 2-0 advantage, Rasmussen gave up a leadoff homer to rookie Chase DeLauter in the sixth inning but retired the next three batters.

With two relievers ready and the bottom of the Guardians order due up, manager Kevin Cash sent out Rasmussen for the seventh. His first pitch was launched 436 feet to center field by light-hitting catcher Patrick Bailey for a tying home run.

“Cashy checked in with me and I told him I was good,” said Rasmussen, who had permitted just one run over 27 2/3 innings until DeLauter connected. “Unfortunately, it just didn’t unfold the way we wanted.”

Nothing went right for the Rays after that.

José Ramírez reached on an infield single to start the eighth and DeLauter drilled a double off Tyler Wells, putting runners at second and third. One out later, left-hander Ian Seymour entered to face left-handed hitter Nathaniel Lowe and allowed a two-run single on an 0-2 fastball as the Guardians grabbed a 4-2 lead.

It was the first deficit this postseason for the AL East champion Rays, who were coming off a three-game sweep of the New York Yankees in their Division Series.

In the opener of that matchup, Rasmussen carried a no-hitter for 7 2/3 innings on the way to a 1-0 victory.

This time, Tampa Bay fell apart late.

After a home run by Cedric Mullins trimmed the deficit to 4-3 in the eighth, Cole Sulser yielded a leadoff single to slumping Angel Martínez in the ninth and balked him to second. Two outs later, Ramírez's soft RBI single made it 5-3.

But the Guardians weren't done.

Ramírez advanced on a wild pitch by Sulser, who then walked DeLauter. Rays sinkerballer Kevin Kelly entered to face Jo Adell, and Ramírez took off from second on a 1-2 pitch.

Third baseman Junior Caminero left his position to cover the bag, and Adell’s hard-hit grounder through the spot vacated by Caminero turned into a two-run double that put Tampa Bay in a 7-3 hole.

“You know what? We were throwing behind,” Cash said. “We were going to throw to second base. DeLauter had gone the first time. I haven’t spoke to Cami about it. We were going to go to second base. I’m guessing Cami recognized that DeLauter didn’t take off and attempted to go to third base. Totally understand how it seemed like the perfect play for the Guardians."

It was a stunning meltdown at Tropicana Field for the Rays, who matched Milwaukee for the best home record in the majors during the regular season. They hadn't lost a game started by Rasmussen since July 9, a string of 13 straight wins.

“I thought he was outstanding. I thought he threw an incredible ballgame,” Cash said. “You've got to give credit to Cleveland’s lineup. They really put some pitches on him and some longer at-bats early on. But I felt like after the third or fourth inning, he really settled in.”

Things nearly got even worse for the Rays in the ninth, when Caminero and left fielder Jonny DeLuca collided while chasing Brayan Rocchio’s foul ball.

Caminero, who had 42 homers, 101 RBIs and an .885 OPS during the regular season, was shaken up on the play but remained in the game after a brief delay.

Cash said he thought the All-Star slugger “just got the wind knocked out of him” but seems to be “totally fine now.”

“I feel good overall. Just my head hurts a little bit, but overall good,” Caminero said. “I was just hit in the chest.”

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