WASHINGTON (AP) — The Biden administration says there is a significant difference between Israeli actions that have expanded its war against the Iranian-backed militant groups Hamas and Hezbollah and Iran’s retaliatory missile attack against Israel, which it condemned as escalatory.

In carefully calibrated remarks, officials across the administration are defending the surge in attacks by Israel against Hezbollah leaders in Lebanon, while still pressing for peace and vowing retribution after Iran fired about 200 ballistic missiles at Israel on Tuesday.

President Joe Biden praised the U.S. and Israel militaries for defeating the barrage and warned, “Make no mistake, the United States is fully, fully supportive of Israel.”

Secretary of State Antony Blinken called the Iranian missile attack “totally unacceptable, and the entire world should condemn it.”

There was little criticism that Israel may have provoked Iran's assault. "Obviously, this is a significant escalation by Iran,” national security adviser Jake Sullivan said.

Just a week after calling urgently for an immediate cease-fire between Israel and Hezbollah to avoid the possibility of all-out war in the Middle East, the administration has shifted its message as Israel presses ahead with ground incursions in Lebanon following a massive airstrike Friday in Beirut that killed Hezbollah leader Hassan Nasrallah and Iranian Revolutionary Guard Gen. Abbas Nilforushan.

U.S. officials stress that they have repeatedly come out in support of Israel’s right to defend itself and that any change in their language only reflects evolving conditions on the ground. And, officials say the administration’s goal — a cease-fire — has remained constant.

The U.S. has been quick to praise and defend Israel for a series of recent strikes killing Hezbollah leaders. In contrast to its repeated criticism of Israel's war in Gaza that has killed civilians, the U.S. has taken a different tack on strikes that targeted Nasrallah and others but also may have killed innocent people.

At the Pentagon, Maj. Gen. Pat Ryder made it clear that while the U.S. is still “laser focused” on preventing a wider conflict in the Middle East, he carved out broad leeway for Israel to keep going after Hezbollah to protect itself.

“We understand and support Israel’s right to defend itself against Hezbollah,” Ryder said. “We understand that part of that is dismantling some of the attack infrastructure that Hezbollah has built along the border.”

He said the U.S. is going to consult with Israel as it conducts limited operations against Hezbollah positions along the border “that can be used to threaten Israeli citizens.” The goal, he said, is to allow citizens on both sides of the border to return to their homes.

Part of the ongoing discussions that the U.S. will have with Israel, Ryder said, will focus on making sure there’s an understanding about potential “mission creep” that could lead to tensions to escalate even further.

State Department spokesman Matthew Miller said Tuesday that Israel’s targeting of senior Hamas and Hezbollah leaders as well as its initiation of ground incursions into Lebanon are justified because they were done in self-defense.

“If you look at the actions that they have taken, they were bringing terrorists to justice, terrorists who have launched attacks on Israeli civilians,” Miller said.

By contrast, he said that Iran’s response was dangerous and escalatory because it was done in support of Hamas and Hezbollah, both of which are U.S.-designated terrorist organizations that Iran funds and supports.

“What you saw (was) Iran launching a state-on-state attack to protect and defend the terrorist groups that it built, nurtured and controlled,” Miller said. “So there is a difference between the actions.”

The full-throated defense of Israel, however, may come with risks. So far, there is little evidence that the Biden administration's push for a cease-fire and warnings of broadening the conflict have had much impact on Israeli Prime Minister Benjamin Netanyahu.

In commentary Monday, Jon Alterman, director of the Middle East program at the Center for Strategic and International Studies in Washington, said that U.S. influence on Netanyahu seems to be waning and that he “seems to have blown by U.S. cautions about starting a regional war.”

The White House must “worry that a sustained inability to make diplomatic progress weakens U.S. influence in the Middle East and around the world,” Alterman said, adding that “Netanyahu’s assurance that the United States will stand by Israel in any circumstance emboldens Israel to take more risks than it otherwise would.”

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Associated Press writer Tara Copp in Washington contributed to this report.